Intrasubject variation in elimination half-lives of drugs which are appreciably metabolized

@article{Wagner1973IntrasubjectVI,
  title={Intrasubject variation in elimination half-lives of drugs which are appreciably metabolized},
  author={John E Wagner},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1973},
  volume={1},
  pages={165-173}
}
It is sometimes assumed in evaluating data from some pharmacokinetic and pharmacogenetic studies that the half-life of elimination of a drug which is appreciably or essentially completely metabolized by man is essentially a constant for a given individual subject. I have run a large number of carefully controlled crossover studies in so-called normal… CONTINUE READING