Intrasubject variability of radial artery flow-mediated dilatation in healthy subjects and implications for use in prospective clinical trials.

@article{Brook2005IntrasubjectVO,
  title={Intrasubject variability of radial artery flow-mediated dilatation in healthy subjects and implications for use in prospective clinical trials.},
  author={Robert D. Brook and Meghan Grau and Christine Kehrer and Santo Dellegrottaglie and Bobby Khan and Sanjay Rajagopalan},
  journal={The American journal of cardiology},
  year={2005},
  volume={96 9},
  pages={1345-8}
}
Flow-mediated dilation (FMD) in the brachial artery is a widely used end point in clinical trials despite large within-subject variability and a small dynamic range. Recent studies suggest that the radial artery may be more advantageous for investigating FMD because of an enhanced vasodilator response. This study therefore assessed the validity and repeatability of radial artery FMD (FMD-R) to evaluate its suitability for the noninvasive evaluation of endothelial function. Thirty-three healthy… CONTINUE READING