Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice.

@article{Hunter2009IntrastriatalLI,
  title={Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice.},
  author={Randy Lee Hunter and Baohua Cheng and Dong Young Choi and Mei Liu and Shuwei Liu and Wayne A. Cass and Guoying Bing},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 8},
  pages={
          1913-21
        }
}
A role for inflammation has been hypothesized in the etiology and progression of Parkinson's disease (PD). In this study, we generated, characterized, and validated the first progressive PD-related mouse model (C57/B6) with intrastriatal injection of lipopolysaccharide (LPS). We showed progressive and specific dopaminergic neurodegeneration in the substantia nigra, which is accompanied by striatal dopamine depletion and progressive behavioral impairment, which was alleviated by the use of the… CONTINUE READING
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