Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

@article{BilangBleuel1997IntrastriatalIO,
  title={Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.},
  author={Alicia Bilang-Bleuel and Fr{\'e}d{\'e}ric Revah and Professor D. Colin and I Locquet and J. J. Robert and Jacques Mallet and Philippe Horellou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 16},
  pages={8818-23}
}
Glial-cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for adult nigral dopamine neurons in vivo. GDNF has both protective and restorative effects on the nigro-striatal dopaminergic (DA) system in animal models of Parkinson disease. Appropriate administration of this factor is essential for the success of its clinical application. Since it cannot cross the blood-brain barrier, a gene transfer method may be appropriate for delivery of the trophic factor to DA cells… CONTINUE READING

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Bilang-Bleuel et al

P. Yeh, J. F. Dedieu, +5 authors 559–565. Neurobiology
Proc. Natl. Acad. Sci. USA 94 • 1997
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