Intrastriatal grafts derived from fetal striatal primordia

@article{Liu2004IntrastriatalGD,
  title={Intrastriatal grafts derived from fetal striatal primordia},
  author={Feng Liu and Stephen B. Dunnett and Harold A. Robertson and Ann M. Graybiel},
  journal={Experimental Brain Research},
  year={2004},
  volume={85},
  pages={501-506}
}
Cocaine, a catecholamine agonist, has been shown to produce a transient induction of the immediate-early gene c-fos and its protein product Fos in the striatum of normal rats. In the present study we report that the expression of Fos can be induced by cocaine challenge in intrastriatal grafts derived from cell suspensions of embryonic striatal primordia. Fos-like immunoreactivity in the nuclei of grafted neurons was detected 2 hr after the injection of 50 mg/kg cocaine into the host rats… CONTINUE READING
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