Intrastriatal dopamine D1 antagonism dampens neural plasticity in response to motor cortex lesion.

@article{Davis2007IntrastriatalDD,
  title={Intrastriatal dopamine D1 antagonism dampens neural plasticity in response to motor cortex lesion.},
  author={Eric H. Davis and Colleen Coyne and Thomas H. Mcneill},
  journal={Neuroscience},
  year={2007},
  volume={146 2},
  pages={784-91}
}
Motor cortex lesions in rats partially denervate the striatum, producing behavioral deficits and inducing reactive neuroplasticity. Plastic responses include changes in growth-associated protein marker expression and anatomical restructuring. Corticostriatal plasticity is dependent on dopamine at the striatal target, where D1 receptor signaling reinforces… CONTINUE READING