Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra.

@article{Nosheny2006IntrastriatalAO,
  title={Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra.},
  author={Rachel L. Nosheny and Alessia Bachis and Sadia A Aden and Maria A De Bernardi and Italo Mocchetti},
  journal={Journal of neurobiology},
  year={2006},
  volume={66 12},
  pages={1311-21}
}
Uninfected neurons of the substantia nigra (SN) degenerate in human immunodeficiency virus (HIV)-positive patients through an unknown etiology. The HIV envelope glycoprotein 120 (gp120) causes apoptotic neuronal cell death in the rodent striatum, but its primary neurotoxic mechanism is still under investigation. Previous studies have shown that gp120 causes… CONTINUE READING