Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes

@article{Naik2006IntrasplenicSD,
  title={Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes},
  author={Shalin H. Naik and Donald Metcalf and Annemarie van Nieuwenhuijze and Ian P. Wicks and Li Wu and Meredith O'Keeffe and Ken Shortman},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={663-671}
}
Immediate precursors of the many subtypes of dendritic cells (DCs) remain obscure. Here we purified a splenic precursor population that produced all splenic CD8+ and CD8− conventional DCs (cDCs) but not plasmacytoid DCs or other lineages. This 'pre-cDC' population included cells 'precommitted' to form either CD8+ or CD8− cDCs. The pre-cDCs, which comprised 0.05% of splenocytes, expressed a CD11cintCD45RAloCD43intSIRP-αintCD4−CD8− major histocompatibility complex class II–negative surface… 
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TLDR
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TLDR
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