Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators.

@article{Tryfonidou2010IntraspeciesDI,
  title={Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators.},
  author={Marianna A Tryfonidou and Herman A. W. Hazewinkel and Frank M. Riemers and Bas Brinkhof and Louis C. Penning and Marcel Karperien},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={299 6},
  pages={E1044-52}
}
Disparities in longitudinal growth within a species can be partly explained by endocrinological differences. We hypothesized that regulatory networks acting locally in the growth plate may also be important. We tested this hypothesis by evaluating the IGF/IGFBP expression, the vitamin D pathway, and the PTHrP-Indian hedgehog (IHH) feedback loop in rib growth plates from 10- and 21-wk-old small- (Miniature Poodles, MP) and large-breed dogs (Great Danes, GD) using immunohistochemistry and… CONTINUE READING

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