Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature

  title={Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature},
  author={Douglas M Heithoff and William R. Shimp and John K. House and Youhua Xie and Bart C. Weimer and Robert L. Sinsheimer and Michael J. Mahan},
  booktitle={PLoS pathogens},
Salmonella is a principal health concern because of its endemic prevalence in food and water supplies, the rise in incidence of multi-drug resistant strains, and the emergence of new strains associated with increased disease severity. Insights into pathogen emergence have come from animal-passage studies wherein virulence is often increased during infection. However, these studies did not address the prospect that a select subset of strains undergo a pronounced increase in virulence during the… CONTINUE READING
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