Intrarenal role of angiotensin II. Homeostatic regulation of renal blood flow in the dog.

@article{Freeman1973IntrarenalRO,
  title={Intrarenal role of angiotensin II. Homeostatic regulation of renal blood flow in the dog.},
  author={Ronald H. Freeman and James O. Davis and S J Vitale and Julie A. Johnson},
  journal={Circulation research},
  year={1973},
  volume={32 6},
  pages={
          692-8
        }
}
The analogue, l-sarcosine-8-alanine-angiotensin II, a specific competitive antagonist of the vascular action of angiotensin II in the rat, blocked the decrease in renal blood flow after a single intrarenal injection of angiotensin II but not after an injection of norepinephrine in normal dogs, in a sodium-depleted dog, and in a dog with thoracic vena caval constriction. Infusion of the analogue at 0.2 /ig/kg mininto the renal artery consistently increased renal blood flow and decreased renal… CONTINUE READING

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Renal Hypertension

  • I. H. PAGE, J. W. MCCUBBIN
  • Chicago, Year Book Medical Publishers, Inc.,
  • 1968
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