Intrarenal purinergic signaling in the control of renal tubular transport.

@article{Praetorius2010IntrarenalPS,
  title={Intrarenal purinergic signaling in the control of renal tubular transport.},
  author={Helle A Praetorius and Jens Leipziger},
  journal={Annual review of physiology},
  year={2010},
  volume={72},
  pages={377-93}
}
Renal tubular epithelial cells receive hormonal input that regulates volume and electrolyte homeostasis. In addition, numerous intrarenal, local signaling agonists have appeared on the stage of renal physiology. One such system is that of intrarenal purinergic signaling. This system involves all the elements necessary for agonist-mediated intercellular communication. ATP is released from epithelial cells, which activates P2 receptors in the apical and basolateral membrane and thereby modulates… CONTINUE READING