Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors.

@article{Kemp2012IntrarenalAI,
  title={Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors.},
  author={Brandon A. Kemp and John F. Bell and Daniele M. Rottkamp and Nancy L. Howell and Weijian Shao and L Gabriel Navar and Shetal H. Padia and R. M. Carey},
  journal={Hypertension},
  year={2012},
  volume={60 2},
  pages={387-95}
}
In angiotensin type 1 receptor-blocked rats, renal interstitial (RI) administration of des-aspartyl(1)-angiotensin II (Ang III) but not angiotensin II induces natriuresis via activation of angiotensin type 2 receptors. In the present study, renal function was documented during systemic angiotensin type 1 receptor blockade with candesartan in Sprague-Dawley rats receiving unilateral RI infusion of Ang III. Ang III increased urine sodium excretion, fractional sodium, and lithium excretion. RI… CONTINUE READING

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