Intrarenal angiotensin II: interstitial and cellular levels and site of production.

  title={Intrarenal angiotensin II: interstitial and cellular levels and site of production.},
  author={Jorge P. van Kats and Maarten A. D. H. Schalekamp and Pieter D. Verdouw and Dirk J. Duncker and Alexander Hj Danser},
  journal={Kidney international},
  volume={60 6},
BACKGROUND Both local production and angiotensin II subtype 1 (AT1) receptor-mediated uptake from the circulation contribute to the high levels of angiotensin (Ang) II in the kidney. It is largely unknown where Ang II is produced in the kidney and how much of it originates from the circulation. METHODS The concentrations of endogenous and 125I-labeled Ang I and II were measured in renal tissue and in blood from pigs receiving systemic infusions of 125I-Ang I. Pigs were either untreated or… CONTINUE READING

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