Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats.

@article{RodrguezPea2004IntrarenalAO,
  title={Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats.},
  author={Ana B. Rodr{\'i}guez-Pe{\~n}a and Francisco Javier Garc{\'i}a-Criado and N{\'e}lida Eleno and M. C. Rodr{\'i}guez Ar{\'e}valo and Jos{\'e} Miguel L{\'o}pez-Novoa},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2004},
  volume={4 10},
  pages={
          1605-13
        }
}
Ischemia reperfusion (I-R)-induced renal damage is reduced by systemic administration of the NO-dependent vasodilator molsidomine. The aim of this study was to estimate the effect of direct intrarenal molsidomine administration on renal dysfunction and inflammatory reaction after experimental I-R in rats, in order to assess only renal NO effects and to obviate its systemic hemodynamic action. Ischemia was induced by renal pedicle ligation (60 min) followed by reperfusion and contralateral… CONTINUE READING
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