Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria

  title={Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria},
  author={Hubert Barennes and H{\'e}l{\`e}ne Sterlingot and Nicholas Nagot and Honor{\'e} M{\'e}da and Martin Kabor{\'e} and Mahamoudou Sanou and Boubacar Nacro and Patrice Bour{\'e}e and Eric Pussard},
  journal={European Journal of Clinical Pharmacology},
Objective. To compare the intrarectal bioavailabilities of two parenteral formulations of quinine most available in French- (Cinchona alkaloid mixture) and English (hydrochloride salt) -speaking areas of Africa. Methods. The pharmacokinetics of quinine was investigated in four groups of 12 children with acute Plasmodium falciparum malaria receiving 8 mg/kg quinine base every 8 h either as hydrochloride salt or Cinchona alkaloid mixture by a slow 4-h intravenous infusion or intrarectal… CONTINUE READING

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Pharmacokinetics of Quinimax suppositories in children with malaria

H Barennes, F Verdier, F Clavier, E Pussard
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Pharmacokinetics of quinine, quinidine and Cinchonine when given as combination.

The Southeast Asian journal of tropical medicine and public health • 1992
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