Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria

@article{Barennes2003IntrarectalPO,
  title={Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria},
  author={Hubert Barennes and H{\'e}l{\`e}ne Sterlingot and Nicholas Nagot and Honor{\'e} M{\'e}da and Martin Kabor{\'e} and Mahamoudou Sanou and Boubacar Nacro and Patrice Bour{\'e}e and Eric Pussard},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={58},
  pages={649-652}
}
Objective. To compare the intrarectal bioavailabilities of two parenteral formulations of quinine most available in French- (Cinchona alkaloid mixture) and English (hydrochloride salt) -speaking areas of Africa. Methods. The pharmacokinetics of quinine was investigated in four groups of 12 children with acute Plasmodium falciparum malaria receiving 8 mg/kg quinine base every 8 h either as hydrochloride salt or Cinchona alkaloid mixture by a slow 4-h intravenous infusion or intrarectal… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 11 references

Pharmacokinetics of Quinimax suppositories in children with malaria

H Barennes, F Verdier, F Clavier, E Pussard
Clin Drug Investig • 1999
View 1 Excerpt

ficacy and pharmacokinetics of a new intrarectal quinine formulation in children with Plasmodium falciparum malaria

H Barennes, E Pussard, +5 authors F Verdier
Br J Clin Pharmacol • 1996

Pharmacokinetics of quinine, quinidine and Cinchonine when given as combination.

The Southeast Asian journal of tropical medicine and public health • 1992
View 2 Excerpts

Similar Papers

Loading similar papers…