Intrarectal Nitric Oxide Administration Prevents Cellular Infiltration but Not Colonic Injury During Dextran Sodium Sulfate Colitis

@article{Vermeiren2012IntrarectalNO,
  title={Intrarectal Nitric Oxide Administration Prevents Cellular Infiltration but Not Colonic Injury During Dextran Sodium Sulfate Colitis},
  author={Joan Vermeiren and Pieter M Hindryckx and Glynn Van Nieuwenhuyse and Debby Laukens and Martine de Vos and Nico Boon and Tom Van de Wiele},
  journal={Digestive Diseases and Sciences},
  year={2012},
  volume={57},
  pages={1832-1837}
}
During inflammation in the gastrointestinal tract, the production of nitric oxide (NO) is mediated by the mucosal conversion of l-arginine. Recently, it was shown that the gut microbiota can also produce NO. The effect of gut luminal NO on inflammatory processes of an experimental colitis mice model was investigated by administrating NO directly to the… CONTINUE READING