Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice.

@article{Allendoerfer1997IntrapulmonaryRT,
  title={Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice.},
  author={Ruth Allendoerfer and George S Deepe},
  journal={Infection and immunity},
  year={1997},
  volume={65 7},
  pages={2564-9}
}
We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acutely infected GKO mice exhibited dramatically elevated numbers of CFU in lungs and significantly higher levels of tumor necrosis factor alpha (TNF-alpha) and granulocyte-macrophage… CONTINUE READING
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Histoplasmosis. A granulomatous inflammatory response, p. 943–958

  • G. S. Deepe, Jr., W. E. Bullock
  • 1992
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