Intrapulmonary pharmacokinetics of azithromycin in healthy volunteers given five oral doses.

@article{Olsen1996IntrapulmonaryPO,
  title={Intrapulmonary pharmacokinetics of azithromycin in healthy volunteers given five oral doses.},
  author={Keith M. Olsen and Gerry S San Pedro and Lilian Gann and Paul O Gubbins and Deborah Halinski and G. Douglas Campbell},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 11},
  pages={2582-5}
}
The intrapulmonary pharmacokinetics of oral azithromycin were studied in 25 healthy volunteers, each of whom received an initial dose of 500 mg and then 250 mg once daily for four additional doses. Bronchoscopy, bronchoalveolar lavage, and venipuncture were performed 4, 28, 76, 124, 172, 244, 340, and 508 h after the first dose was administered. Azithromycin concentrations in epithelial lining fluid (ELF), alveolar macrophages, peripheral blood monocytes, and serum were measured by high… CONTINUE READING