Intrapulmonary penetration of linezolid.

@article{Honeybourne2003IntrapulmonaryPO,
  title={Intrapulmonary penetration of linezolid.},
  author={David Honeybourne and Catherine D. Tobin and G. M. Jevons and Jenny M. Andrews and Richard Wise},
  journal={The Journal of antimicrobial chemotherapy},
  year={2003},
  volume={51 6},
  pages={
          1431-4
        }
}
OBJECTIVE This study was designed to measure the concentrations of linezolid in bronchial mucosa, pulmonary macrophages and epithelial lining fluid and to compare them with simultaneous blood levels. METHODS Ten adult patients undergoing bronchoscopy for diagnostic purposes were given oral linezolid at a dosage of 600 mg twice a day for a total of six doses. Patients with active lung infection were excluded from the study. Flexible bronchoscopy was carried out between 2 and 8 h after the last… CONTINUE READING
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