Intrapulmonary catabolism of surfactant-saturated phosphatidylcholine in rabbits.

  title={Intrapulmonary catabolism of surfactant-saturated phosphatidylcholine in rabbits.},
  author={Evelyn D Rider and Machiko Ikegami and Alan Hall Jobe},
  journal={Journal of applied physiology},
  volume={69 5},
Intrapulmonary surfactant catabolism was investigated by use of a phospholipase A1- and A2-resistant analogue of dipalmitoylphosphatidylcholine (DPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPC ether). [14C]DPC ether, made into liposomes with [3H]DPC and associated with 32P-labeled rabbit surfactant, was given intratracheally to 1-kg rabbits, which were killed at preset times to 48 h. Recoveries of radiolabel as saturated phosphatidylcholine (Sat PC) isolated from alveolar wash (AW… CONTINUE READING
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