Intraprotein electron transfer and proton dynamics during photoactivation of DNA photolyase from E. coli: review and new insights from an "inverse" deuterium isotope effect.

@article{Byrdin2004IntraproteinET,
  title={Intraprotein electron transfer and proton dynamics during photoactivation of DNA photolyase from E. coli: review and new insights from an "inverse" deuterium isotope effect.},
  author={Martin Byrdin and Val{\'e}rie Sartor and Andr{\'e} Eker and Marten H Vos and Corinne Aubert and Klaus Brettel and Paul Mathis},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1655 1-3},
  pages={64-70}
}
We review our work on electron transfer and proton dynamics during photoactivation in DNA photolyase from E. coli and discuss a recent theoretical study on this issue. In addition, we present unpublished data on the charge recombination between the fully reduced FADH(-) and the neutral (deprotonated) radical of the solvent exposed tryptophan W306. We found a pronounced acceleration with decreasing pH and an inverse deuterium isotope effect (k(H)/k(D)=0.35 at pL 6.5) and interpret it in a model… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

EPR on Flavoproteins.

Methods in molecular biology • 2014
View 1 Excerpt

Magnetically sensitive light-induced reactions in cryptochrome are consistent with its proposed role as a magnetoreceptor.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Theoretical basis and mechanistic utility of solvent isotope effects

D. M. Quinn, L. D. Sutton
in: P.F. Cook (Ed.), Enzyme Mechanism from Isotope Effects, CRC Press, Boca Raton • 1991
View 14 Excerpts
Highly Influenced

Energetics of radical transfer in DNA photolyase.

Journal of the American Chemical Society • 2002
View 6 Excerpts
Highly Influenced

Oxidation of tryptophan and N-methylindole by N3 S

S. Solar, G. Getoff, P. S. Surdhar, D. A. Armstrong, A. Singh
Br2 S , and (SCN)2 S radicals in light- and heavy-water solutions: a pulse radiolysis study, J. Phys. Chem. 95 • 1991
View 4 Excerpts
Highly Influenced

Dissection of the triple tryptophan electron transfer chain in E . coli DNA Photolyase : Trp 382 is the primary donor in photoactivation

A. P. M. Eker Byrdin, M. H. Vos, K. Brettel
Proc . Natl . Acad . Sci . U . S . A . • 2003

Molecular Mechanisms of Photosynthesis

R. E. Blankenship
Blackwell, Oxford • 2002
View 1 Excerpt

Ultrafast spectroscopy of the excited flavin radical and its primary photoproduct in DNA photolyase from E

M. Byrdin, K. Brettel, C. Aubert, A.P.M. Eker, M. H. Vos
coli, in: S. Chapman, R. Perham, N. Scrutton (Eds.), Flavins and Flavoproteins 2002, Rudolph Weber, Agency for Scientific Publications, Berlin • 2002

Similar Papers

Loading similar papers…