Intraportal transplantation of pancreatic islets into livers of diabetic rats. Reinnervation of islets and regulation of insulin secretion by the hepatic sympathetic nerves.

@article{Gardemann1994IntraportalTO,
  title={Intraportal transplantation of pancreatic islets into livers of diabetic rats. Reinnervation of islets and regulation of insulin secretion by the hepatic sympathetic nerves.},
  author={Andreas Gardemann and Kurt Jungermann and Volker Grosse and Lothar Cossel and Frank Wohlrab and Hwa Jeong Hahn and W Blech and Wesley Hildebrandt},
  journal={Diabetes},
  year={1994},
  volume={43 11},
  pages={1345-52}
}
Two weeks after intraportal transplantation of 2,000 neonatal pancreatic islets, recipient rats completely recovered from streptozotocin-induced diabetes. The reversal of diabetes could be documented by the normalization of blood glucose levels, by a restored weight gain, by normal glucagon and insulin levels in blood, and by a disappearance of polyuria and polydipsia. The reversal remained stable for at least 9 months. This study determined whether intraportally transplanted pancreatic islets… CONTINUE READING

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