Intraportal administration of neuropeptide Y and hepatic glucose metabolism.

@article{Nishizawa2008IntraportalAO,
  title={Intraportal administration of neuropeptide Y and hepatic glucose metabolism.},
  author={Makoto Nishizawa and Masakazu Shiota and Mary Courtney Moore and Stephanie M. Gustavson and Doss W. Neal and Alan D. Cherrington},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 4},
  pages={
          R1197-204
        }
}
We examined whether intraportal delivery of neuropeptide Y (NPY) affects glucose metabolism in 42-h-fasted conscious dogs using arteriovenous difference methodology. The experimental period was divided into three subperiods (P1, P2, and P3). During all subperiods, the dogs received infusions of somatostatin, intraportal insulin (threefold basal), intraportal glucagon (basal), and peripheral intravenous glucose to increase the hepatic glucose load twofold basal. Following P1, in the NPY group (n… 
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