Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels.

@article{Johnson2007IntraportalGI,
  title={Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels.},
  author={Kathryn M. S. Johnson and Dale S. Edgerton and Tiffany D Rodewald and Melanie Scott and Ben Farmer and Doss Neal and Alan D. Cherrington},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 4},
  pages={E1085-91}
}
After a meal, glucagon-like peptide-1 (GLP-1) levels in the hepatic portal vein are elevated and are twice those in peripheral blood. The aim of this study was to determine whether any of GLP-1's acute metabolic effects are initiated within the hepatic portal vein. Experiments consisted of a 40-min basal period, followed by a 240-min experimental period, during which conscious 42-h-fasted dogs received glucose intraportally (4 mgxkg(-1)xmin(-1)) and peripherally (as needed) to maintain arterial… CONTINUE READING
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