Intrapleural hyperthermic perfusion with chemotherapy increases apoptosis in malignant pleuritis.

  title={Intrapleural hyperthermic perfusion with chemotherapy increases apoptosis in malignant pleuritis.},
  author={Yasunori Matsuzaki and Masao Edagawa and Tetsuya M. Shimizu and Masaki Hara and Masaki Tomita and Takanori Ayabe and Toshio Onitsuka},
  journal={The Annals of thoracic surgery},
  volume={78 5},
BACKGROUND Previously, we reported on the effectiveness of intrapleural hyperthermic perfusion with chemotherapy, a new treatment we developed for patients with malignant pleuritis. The present study analyzes the mechanism of the effectiveness of this therapy by examining the induction ratio of apoptosis among tumor cells following the perfusion treatment. METHODS This study included 11 consecutive patients with primary pulmonary adenocarcinoma and accompanying pleural seedlings and pleural… CONTINUE READING


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