Intrapleural administration of OK432 in cancer patients: activation of NK cells and reduction of suppressor cells.

@article{Uchida1983IntrapleuralAO,
  title={Intrapleural administration of OK432 in cancer patients: activation of NK cells and reduction of suppressor cells.},
  author={Atsushi Uchida and Michael Micksche},
  journal={International journal of cancer},
  year={1983},
  volume={31 1},
  pages={1-5}
}
Twelve patients with carcinomatous pleural effusions were treated with single intrapleural (i.pl.) administration of OK432 on day 0 and the effects of i.pl. OK432 on natural killer (NK) cell activity were followed on day 7. Two patients showed no clinical evidence of therapeutic benefit from i.pl. OK432. In the other 10 patients, pleural effusions and/or tumor cells in the effusions had decreased or disappeared by day 7. NK cell activity was markedly low or absent in pleural effusions of… CONTINUE READING