Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat

  title={Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat},
  author={Prisca Honore and Jaroslava Buritova and Jean Marie Besson},
  journal={British Journal of Pharmacology},
1 We have studied the effects of intraplantar administration of the same doses of morphine on intraplantar carrageenin (6 mg 150 μ***l−1 of saline) and noxious heat (52°C for 15 s) induced spinal c‐Fos expression and inflammation. 2 Intraplantar carrageenin, in awake rats, induced numerous Fos‐like immunoreactive (Fos‐LI) neurones in the dorsal horn of L4‐L5 lumbar segments of the spinal cord and extensive peripheral oedema. At 1 h 30 min, Fos‐LI neurones were preferentially located in the… 

Endomorphin-1 reduces carrageenan-induced Fos expression in the rat spinal dorsal horn

Results provided a strong evidence for involvement of mu opioid receptor in peripheral analgesia, particularly in inflammation pain, in rats.

Effects of local anaesthetics on carrageenan-evoked inflammatory nociceptive processing in the rat.

Intraplantar infiltration with lignocaine and bupivacaine before carrageenan transiently limited signs of inflammatory pain but did not prevent them.

Intrathecally Injected Morphine Inhibits Inflammatory Paw Edema: The Involvement of Nitric Oxide and Cyclic-Guanosine Monophosphate

The idea that morphine can act on opioid receptors at the spinal level to produce antiedematogenic effect is supported, and that the NO/cGMP pathway seems to be an important mediator in this effect.

Maturation of NK1 receptor involvement in the nociceptive response to formalin

Results indicate that, within the spinal cord, NK1 receptors start to play a role in the pain response to formalin between 10 and 21 days, and analgesia induced by systemic or local injection of NK1 antagonists involves mechanisms other than, or in addition to, the NK1 receptor.



Reduction of carrageenin oedema and the associated c‐Fos expression in the rat lumbar spinal cord by nitric oxide synthase inhibitor

There is a strong correlation between the reduction of the number of Fos‐LI neurones and the oedema by l‐NAME, clearly demonstrating a predominant role of peripheral NO in the development of one of the signs of carrageenin inflammation.

CP‐93,129, sumatriptan, dihydroergotamine block c‐fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges

It is inferred that treatment with 5‐HT1B/d agonists may be useful for the alleviation of pain in other headache conditions associated with meningeal irritation and that 5‐ HT1D receptor‐mediated blockade of neurotransmission contributes significantly to the analgesic effects of these drugs in headache.

Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord

The effect of systemic morphine on Fos-like immunoreactivity (FLI) evoked in the formalin test, a widely used model of persistent pain, and the dose-response relationship of morphine-induced suppression of FLI varied in different laminae indicate that analgesia from systemic opiates involves differential regulation of nociceptive processing in subpopulations of spinal nocICEptive neurons.

Morphine or U‐50,488 suppresses fos protein‐like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat

It is suggested that morphine and U‐50,488 have comparable effects on the transmission of visceral nociceptive messages by spinal neurons, but differentially affect the autonomic response to noxious visceral stimuli.