Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat

@article{Honore1996IntraplantarMD,
  title={Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat},
  author={Prisca Honore and Jaroslava Buritova and Jean Marie Besson},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={118}
}
1 We have studied the effects of intraplantar administration of the same doses of morphine on intraplantar carrageenin (6 mg 150 μ***l−1 of saline) and noxious heat (52°C for 15 s) induced spinal c‐Fos expression and inflammation. 2 Intraplantar carrageenin, in awake rats, induced numerous Fos‐like immunoreactive (Fos‐LI) neurones in the dorsal horn of L4‐L5 lumbar segments of the spinal cord and extensive peripheral oedema. At 1 h 30 min, Fos‐LI neurones were preferentially located in the… 

Endomorphin-1 reduces carrageenan-induced Fos expression in the rat spinal dorsal horn

Results provided a strong evidence for involvement of mu opioid receptor in peripheral analgesia, particularly in inflammation pain, in rats.

Effects of local anaesthetics on carrageenan-evoked inflammatory nociceptive processing in the rat.

Intraplantar infiltration with lignocaine and bupivacaine before carrageenan transiently limited signs of inflammatory pain but did not prevent them.

Intrathecally Injected Morphine Inhibits Inflammatory Paw Edema: The Involvement of Nitric Oxide and Cyclic-Guanosine Monophosphate

The idea that morphine can act on opioid receptors at the spinal level to produce antiedematogenic effect is supported, and that the NO/cGMP pathway seems to be an important mediator in this effect.

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