Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat

@article{Honore1996IntraplantarMD,
  title={Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat},
  author={Prisca Honore and Jaroslava Buritova and Jean Marie Besson},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={118}
}
1 We have studied the effects of intraplantar administration of the same doses of morphine on intraplantar carrageenin (6 mg 150 μ***l−1 of saline) and noxious heat (52°C for 15 s) induced spinal c‐Fos expression and inflammation. 2 Intraplantar carrageenin, in awake rats, induced numerous Fos‐like immunoreactive (Fos‐LI) neurones in the dorsal horn of L4‐L5 lumbar segments of the spinal cord and extensive peripheral oedema. At 1 h 30 min, Fos‐LI neurones were preferentially located in the… 

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