Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

  title={Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk},
  author={Oksana Ivashchenko and Paul P Van Veldhoven and Chantal Brees and Ye-shih Ho and Stanley R. Terlecky and Marc Fransen},
  booktitle={Molecular biology of the cell},
Reactive oxygen species (ROS) are at once unsought by-products of metabolism and critical regulators of multiple intracellular signaling cascades. In nonphotosynthetic eukaryotic cells, mitochondria are well-investigated major sites of ROS generation and related signal initiation. Peroxisomes are also capable of ROS generation, but their contribution to cellular oxidation-reduction (redox) balance and signaling events are far less well understood. In this study, we use a redox-sensitive variant… CONTINUE READING
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