Intraperitoneal treatment with dimethylthioampal (DIMATE) combined with surgical debulking is effective for experimental peritoneal carcinomatosis in a rat model

@article{Monneuse2007IntraperitonealTW,
  title={Intraperitoneal treatment with dimethylthioampal (DIMATE) combined with surgical debulking is effective for experimental peritoneal carcinomatosis in a rat model},
  author={O. Monneuse and Jean-Philippe Mestrallet and G. Quash and F. Gilly and O. Glehen},
  journal={Journal of Gastrointestinal Surgery},
  year={2007},
  volume={9},
  pages={769-774}
}
  • O. Monneuse, Jean-Philippe Mestrallet, +2 authors O. Glehen
  • Published 2007
  • Medicine
  • Journal of Gastrointestinal Surgery
  • The goal was to evaluate the efficiency of intraperitoneal administration of dimethylthioampal (DIMATE), a cellular apoptosis inducer, combined, or not, with cytoreductive surgery on rats with peritoneal adenocarcinomatosis. Peritoneal carcinomatosis was induced in rats by intraperitoneal injection of adenocarcinoma cell line DHD/K12/pro B. Intraperitoneal DIMATE was given at 17.3 mg/kg. Rats were randomized into five groups of eight animals, regarding the day of treatment (2 days or 20 days… CONTINUE READING
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