Intraperitoneal mitoxantrone: a feasibility and pharmacokinetic study.

  title={Intraperitoneal mitoxantrone: a feasibility and pharmacokinetic study.},
  author={Dario Civalleri and Maria Ornella Vannozzi and F De Cian and Gianluigi Lunardi and M Steinweg and Ilaria Pastrone and Maurizio Viale and Mauro Esposito},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  volume={28 2},
Fractionated doses have been advocated to prevent chemoperitonitis after intraperitoneal infusion of mitoxantrone. Patients with peritoneal carcinomatosis of various origin underwent surgery, including intestinal resections, with minimal residual disease. Peritoneal mitoxantrone in 1000 ml/m(2) saline was planned on the first post-operative day in groups of… CONTINUE READING