Intraperitoneal insulin therapy corrects abnormalities in cholesteryl ester transfer and lipoprotein lipase activities in insulin-dependent diabetes mellitus.

@article{Bagdade1994IntraperitonealIT,
  title={Intraperitoneal insulin therapy corrects abnormalities in cholesteryl ester transfer and lipoprotein lipase activities in insulin-dependent diabetes mellitus.},
  author={John D Bagdade and Fredrick L. Dunn and Robert H Eckel and Mary C. Ritter},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1994},
  volume={14 12},
  pages={1933-9}
}
Patients with insulin-dependent diabetes mellitus (IDDM) have proatherogenic disturbances in cholesteryl ester transfer (CET) despite intensive subcutaneous insulin therapy (ISC). Since CET is activated by insulin-sensitive lipoprotein lipase (LPL), which normally increases postprandially, we queried whether iatrogenic hyperinsulinism from ISC stimulated LPL and CET by studying well-controlled IDDM patients after ISC and then 6 months after lowering systemic insulin levels by intraperitoneal… CONTINUE READING
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