Intraperitoneal infection with scrapie is established within minutes of injection and is non-specifically enhanced by a variety of different drugs

@article{Kimberlin1990IntraperitonealIW,
  title={Intraperitoneal infection with scrapie is established within minutes of injection and is non-specifically enhanced by a variety of different drugs},
  author={Richard H. Kimberlin and Carol A. Walker},
  journal={Archives of Virology},
  year={1990},
  volume={112},
  pages={103-114}
}
Single intraperitoneal (i.p.) doses of 16 different drugs were given to mice 2 h before injecting scrapie i.p. Scrapie was injected as serial ten-fold dilutions of standard inocula and the effective titres obtained were used as a measure of the relative efficiency of infection in treated compared to saline injected mice. Despite the wide variety of drugs tested, most of them increased, non-specifically, the efficiency of infection by 0.6 to 2.1 log10 i.p. LD50 units (i.e., 4 to 126-fold), but… CONTINUE READING

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