Intraperitoneal chemotherapy with melphalan.

  title={Intraperitoneal chemotherapy with melphalan.},
  author={Stephen B. Howell and Craig E. Pfeifle and Richard A. Olshen},
  journal={Annals of internal medicine},
  volume={101 1},
We administered melphalan by the intraperitoneal route to investigate its toxicity and pharmacokinetics. The drug was instilled with 2 litres of fluid and allowed to dwell in the peritoneal cavity for 4 hours. No local toxicity was detected by clinical examination, laboratory tests, or histologic examination. The intraperitoneal route allowed the dose to be increased to approximately three times the maximum dose tolerated intravenously before drug leaking into the systemic circulation produced… CONTINUE READING


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