Intraperitoneal administration of methylene blue attenuates oxidative stress, increases peritoneal fibrinolysis, and inhibits intraabdominal adhesion formation.

@article{Heydrick2007IntraperitonealAO,
  title={Intraperitoneal administration of methylene blue attenuates oxidative stress, increases peritoneal fibrinolysis, and inhibits intraabdominal adhesion formation.},
  author={Stanley J Heydrick and Karen L. Reed and Philip A. Cohen and Cary B. Aarons and Adam C. Gower and James M. Becker and Arthur F. Stucchi},
  journal={The Journal of surgical research},
  year={2007},
  volume={143 2},
  pages={311-9}
}
BACKGROUND Mounting evidence indicates that postoperative oxidative stress may be linked to decreased fibrinolytic activity and, subsequently, the development of intraabdominal adhesions. The goal of this study was to determine if methylene blue, a highly redox active dye that has been shown to inhibit adhesion formation (1) acts as an antioxidant in the postoperative peritoneum, and (2) subsequently affects fibrinolytic activity. MATERIALS AND METHODS Intraabdominal adhesions were surgically… CONTINUE READING

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