Intraperitoneal PACAP administration decreases blood glucose in GK rats, and in normal and high fat diet mice.

@article{Yada2000IntraperitonealPA,
  title={Intraperitoneal PACAP administration decreases blood glucose in GK rats, and in normal and high fat diet mice.},
  author={Toshihiko Yada and Maya Sakurada and Karin Filipsson and Masatoshi Kikuchi and Bo Ahr{\'e}n},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={921},
  pages={259-63}
}
PACAP is an islet peptide that serves as an endogenous amplifier of glucose induced insulin secretion. Furthermore, we has recently found that PACAP also potentiates insulin stimulated glucose uptake in adipocytes. Therefore, an antidiabetic action of PACAP is possible. In the present study, we examined the effect of PACAP treatment of the hyperglycemia in GK rats, an animal model of type 2 diabetes, and in high fat fed C47BL/6J mice, an animal model for glucose intolerance. GK rats housed with… CONTINUE READING

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