Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat.

@article{Palazzo2009IntraperiaqueductalGG,
  title={Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat.},
  author={Enza Palazzo and Francesca Guida and Annalucia Migliozzi and Luisa Gatta and Ida Marabese and Livio Luongo and Claudia Rossi and Vito de Novellis and Enrique Fern{\'a}ndez-S{\'a}nchez and Marie Soukupov{\'a} and Francisco Zafra and Sabatino Maione},
  journal={Journal of neurophysiology},
  year={2009},
  volume={102 6},
  pages={3169-79}
}
We have studied the involvement of the N-methyl-D-aspartate receptor (NMDAR) glycine site and the strychnine-sensitive glycine receptor (GlyR) in the ventrolateral periaqueductal gray (VL-PAG) on nociceptive behavior (tail flick) and pain-related changes on neuronal activity in the rostral ventromedial medulla (RVM). Glycine or D-serine increased the tail-flick latency, reduced OFF-cell pause, and delayed its onset and increased the time between the onset of the OFF-cell pause and the tail… CONTINUE READING

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