• Medicine
  • Published in Clinical pharmacy 1988

Intrapatient variation of aminoglycoside pharmacokinetics in critically ill surgery patients.

@article{Fuhs1988IntrapatientVO,
  title={Intrapatient variation of aminoglycoside pharmacokinetics in critically ill surgery patients.},
  author={D W Fuhs and Henry J. Mann and C A Kubajak and Frank B. Cerra},
  journal={Clinical pharmacy},
  year={1988},
  volume={7 3},
  pages={
          207-13
        }
}
Intrapatient variation in aminoglycoside pharmacokinetics was studied in 100 critically ill surgery patients, and the relationships between aminoglycoside pharmacokinetics and physiological variables were evaluated. A one-compartment model and the DataMed Clinical Support Service System were used to calculate pharmacokinetic values from serum concentration-time data and to provide individualized dosage regimens. A total of 323 pharmacokinetic analyses (2 to 9 per patient) were performed. There… CONTINUE READING

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