Intraoperative serum and tissue activity of cefazolin and cefoxitin.

  title={Intraoperative serum and tissue activity of cefazolin and cefoxitin.},
  author={Joseph T Dipiro and J J Vallner and Talmadge A Bowden and Barbara A. Clark and J F Sisley},
  journal={Archives of surgery},
  volume={120 7},
We determined the intraoperative serum and wound-muscle concentrations of cefazolin and cefoxitin in 40 patients who were undergoing cholecystectomies. The study employed an open-label design in which all of the patients randomly received cefazolin sodium (20 mg/kg) or cefoxitin sodium (30 mg/kg) intravenously while the patient was in the ward ("on call") or with the induction of anesthesia. Multiple blood and wound-muscle samples were collected intraoperatively and assayed for their… CONTINUE READING

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