Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity.

@article{Toms2005IntraoperativeOS,
  title={Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity.},
  author={Steven A. Toms and Wei-Chiang Lin and Robert J. Weil and Mahlon D. Johnson and E. Duco Jansen and Anita Mahadevan-Jansen},
  journal={Neurosurgery},
  year={2005},
  volume={61 1 Suppl},
  pages={327-35; discussion 335-6}
}
OBJECTIVE Adult gliomas have indistinct borders. As the ratio of neoplastic cells to normal cells becomes lower, the ability to detect these cells diminishes. We describe a device designed to augment intraoperative identification of both solid tumor and infiltrating tumor margins. METHODS A novel, intraoperative, optical spectroscopic tool, using both white light reflectance and 337-nm excitation fluorescence spectroscopy, is described. Discrimination algorithms have been developed to… CONTINUE READING