Intraoperative molecular analysis of total tumor load in sentinel lymph node: a new predictor of axillary status in early breast cancer patients

@article{Peg2013IntraoperativeMA,
  title={Intraoperative molecular analysis of total tumor load in sentinel lymph node: a new predictor of axillary status in early breast cancer patients},
  author={Vicente Peg and Mart{\'i}n Espinosa-Bravo and Bego{\~n}a Vieites and Felip Vilardell and Jos{\'e} Ram{\'o}n Ant{\'u}nez and Magdalena Sancho de Salas and Julio J. Delgado-S{\'a}nchez and Willy Pinto and Francisco Gozalbo and Anna Petit and Irene Sansano and Mar{\'i}a del Mar T{\'e}llez and Isabel Teresa Rubio},
  journal={Breast Cancer Research and Treatment},
  year={2013},
  volume={139},
  pages={87-93}
}
Objective To assess the intraoperative positive sentinel lymph node (SLN) total tumor load (TTL, defined as the amount of CK19 mRNA copies [copies/μL] in all positive SLNs) obtained by one-step nucleic acid amplification (OSNA) and to determine whether it is predictive of non-SLNs involvement. Summary background data The OSNA assay (Sysmex Corporation, Kobe, Japan) is a new diagnostic technique that uses molecular biological techniques to analyze SLN that has been validated as an accurate… CONTINUE READING