Intraoperative irradiation of the canine pancreas: short-term effects.

  title={Intraoperative irradiation of the canine pancreas: short-term effects.},
  author={Henk J. A. M. Heijmans and Dinesh Mehta and Jan H. Kleibeuker and Wim J. Sluiter and J Marja Oldhoff and Harald Joan Hoekstra},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={29 3},
Intraoperative electron beam radiotherapy (IORT) is clinically used as a potential adjunctive treatment to surgery of locally advanced pancreatic and gastric cancer. The tolerance of the pancreas to IORT was studied in 15 adult beagles, divided in 3 groups of 5 beagles in which 25, 30 or 35 Gy IORT was delivered through a 6-7 cm circular lucite cone with 6-8 MeV electrons to the pancreas and medial wall of the duodenum. The dogs were followed for endocrine and exocrine pancreatic insufficiency… CONTINUE READING