Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers.

@article{Tanihara2008IntraocularPE,
  title={Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers.},
  author={Hidenobu Tanihara and Masaru Inatani and Megumi Honjo and Hideki Tokushige and Junichi Azuma and Makoto Araie},
  journal={Archives of ophthalmology},
  year={2008},
  volume={126 3},
  pages={309-15}
}
OBJECTIVE To investigate the effects and safety of topical administration of an ophthalmic solution of a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, SNJ-1656, 0.003% to 0.1%, in healthy male adult volunteers. DESIGN Randomized, double-masked, group-comparison, phase 1 clinical study. In the initial single-instillation trial, 45 healthy volunteers were randomly subdivided into 5 groups and treated with SNJ-1656 in concentrations of 0.003%, 0.01%, 0.03%, 0.05… CONTINUE READING
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