Intraocular injection of class II-restricted peptide induces an unexpected population of CD8 regulatory cells.

@article{Kosiewicz1996IntraocularIO,
  title={Intraocular injection of class II-restricted peptide induces an unexpected population of CD8 regulatory cells.},
  author={Michele M. Kosiewicz and J. Wayne Streilein},
  journal={Journal of immunology},
  year={1996},
  volume={157 5},
  pages={
          1905-12
        }
}
Intraocular injection of exogenous protein induces an Ag-specific impairment of systemic delayed hypersensitivity (DH), termed anterior chamber associated immune deviation (ACAID). The ACAID-inducing signal is carried by blood-borne cells from the eye to the spleen and can also be generated in vitro by incubating APCs with Ag plus TGF-beta. Paradoxically, class I-restricted CD8 regulatory cells are induced in the spleens of mice with ACAID, and previous studies suggest that CD8 cells are… CONTINUE READING

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