Intranodal immunization with a vaccinia virus encoding multiple antigenic epitopes and costimulatory molecules in metastatic melanoma.

@article{Adamina2010IntranodalIW,
  title={Intranodal immunization with a vaccinia virus encoding multiple antigenic epitopes and costimulatory molecules in metastatic melanoma.},
  author={Michel Adamina and Rachel Rosenthal and Walter P Weber and Daniel M. Frey and Carsten Thomas Viehl and Martin Bolli and Rolf W. Huegli and Augustinus Ludwig Jacob and Michael M. G. Heberer and Daniel Oertli and Walter Richard Marti and Giulio Cesare Spagnoli and Paul Zajac},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 3},
  pages={651-9}
}
Recombinant vaccinia virus (rVV) encoding tumor-associated antigens (TAAs) and adhesion or costimulatory molecules may represent important immunogenic reagents for cancer immunotherapy. Recently, intranodal (IN) antigen administration was suggested to be more immunogenic than intradermal (ID) vaccination. However, IN rVV administration has not been attempted so far. We used a rVV encoding gp100(280-288), Melan-A/MART-1(27-35) and tyrosinase(1-9) HLA-A0201 restricted epitopes and CD80 and CD86… CONTINUE READING
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