Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat

@article{Castillo2006IntranigralTO,
  title={Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat},
  author={Claudia G Castillo and Soledad Acu{\~n}a Mendoza and William J. Freed and Magda Giordano},
  journal={Behavioural Brain Research},
  year={2006},
  volume={171},
  pages={109-115}
}
Repeated systemic administration of low doses of kainic acid (KA) induces spontaneous convulsive seizures [Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 1998;31:73-84]. In this study, male Sprague-Dawley animals received intranigral transplants of a control cell line M213-2O, or a cell line transfected with human GAD67 cDNA (M213-2O… CONTINUE READING
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