Intraneuronal compartments of the amyloid precursor protein.

  title={Intraneuronal compartments of the amyloid precursor protein.},
  author={Ana C{\'a}ssia S Ferreira and Alfredo C{\'a}ceres and Kenneth S. Kosik},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={13 7},
The amyloid precursor protein (APP) is the parent molecule from which beta-amyloid protein is cleaved and deposits as amyloid fibrils in the senile plaques of Alzheimer's disease. Its primary structure resembles a receptor; however, no ligand has been identified. In growing hippocampal neurons APP is localized to growth cones. APP immunoreactivity was highly enriched in the axons of mature cultured neurons, where it appears as a specialization of the axonal membrane. Its anterograde… CONTINUE READING