Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

@article{Crowther2005IntraneuronalAN,
  title={Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.},
  author={Damian C Crowther and Kerri J Kinghorn and Elena Miranda and R Priscilla Page and James A. Curry and Fiona A I Duthie and David C Gubb and David A. Lomas},
  journal={Neuroscience},
  year={2005},
  volume={132 1},
  pages={123-35}
}
We have developed models of Alzheimer's disease in Drosophila melanogaster by expressing the Abeta peptides that accumulate in human disease. Expression of wild-type and Arctic mutant (Glu22Gly) Abeta(1-42) peptides in Drosophila neural tissue results in intracellular Abeta accumulation followed by non-amyloid aggregates that resemble diffuse plaques. These histological changes are associated with progressive locomotor deficits and vacuolation of the brain and premature death of the flies. The… CONTINUE READING
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