Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.

@article{Scala2015IntraneuronalAA,
  title={Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.},
  author={Federico Scala and Salvatore Fusco and Cristian Ripoli and Roberto Piacentini and Domenica Donatella Li Puma and Matteo Spinelli and Fernanda Laezza and Claudio Grassi and Marcello D'Ascenzo},
  journal={Neurobiology of aging},
  year={2015},
  volume={36 2},
  pages={886-900}
}
Amyloid β-protein (Aβ) pathologies have been linked to dysfunction of excitability in neurons of the hippocampal circuit, but the molecular mechanisms underlying this process are still poorly understood. Here, we applied whole-cell patch-clamp electrophysiology to primary hippocampal neurons and show that intracellular Aβ42 delivery leads to increased spike discharge and action potential broadening through downregulation of A-type K(+) currents. Pharmacologic studies showed that caspases and… CONTINUE READING
Highly Cited
This paper has 33 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Endoplasmic reticulum stress induces spatial memory deficits by activating GSK‐3

Journal of cellular and molecular medicine • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…