Intranasally administered pitavastatin ameliorates pentylenetetrazol‐induced neuroinflammation, oxidative stress and cognitive dysfunction

  title={Intranasally administered pitavastatin ameliorates pentylenetetrazol‐induced neuroinflammation, oxidative stress and cognitive dysfunction},
  author={Ashif Iqubal and Sumit Sharma and Kalicharan Sharma and Ashish Bhavsar and Ibrahim Hussain and Mohammad Kashif Iqubal and Ratendra Kumar},
  journal={Life Sciences},
Aim: The present study aimed to evaluate the neuroprotective potential of intranasally administered pitavastatin in the PTZ‐induced kindling model. Materials and methods: Subconvulsant dose of PTZ (35 mg/kg, i.p) was administered on an alternate day until the development of kindling. Behavioural test, biochemical tests and inflammatory cytokines were estimated. Comparative molecular docking study of sodium valproate (VPA) and pitavastatin was performed to predict the binding affinity with GABAA… Expand
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